Journal article
White matter tract conductivity is resistant to wide variations in paranodal structure and myelin thickness accompanying the loss of Tyro3: an experimental and simulated analysis
F Blades, JD Chambers, TD Aumann, CTO Nguyen, VHY Wong, A Aprico, EC Nwoke, BV Bui, DB Grayden, TJ Kilpatrick, MD Binder
Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2022
Abstract
Myelination within the central nervous system (CNS) is crucial for the conduction of action potentials by neurons. Variation in compact myelin morphology and the structure of the paranode are hypothesised to have significant impact on the speed of action potentials. There are, however, limited experimental data investigating the impact of changes in myelin structure upon conductivity in the central nervous system. We have used a genetic model in which myelin thickness is reduced to investigate the effect of myelin alterations upon action potential velocity. A detailed examination of the myelin ultrastructure of mice in which the receptor tyrosine kinase Tyro3 has been deleted showed that, in..
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Awarded by Trish Multiple Sclerosis Research Foundation
Funding Acknowledgements
Funding for this project was provided by The Trish Multiple Sclerosis Research Foundation to TJK and MB (17-0216), as well as an Australian Research Council Linkage Grant to CTON and BB (LP160100126). FB was supported by the Australian Government Research Training Program Scholarship. JDC was supported by the Australian Research Council Industrial Transformation Training Centre in Cognitive Computing for Medical Technologies (project number ICI70200030). CTON was supported by a Melbourne Research Fellowship. TJK was supported by an Investigator grant from the NH&MRC (#APP1175775). The Florey Institute of Neuroscience and Mental Health acknowledges the support received from the Victorian Government, in particular, the funding from the Operational Infrastructure Support Grant.